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(Medical-NewsWire.com, December 10, 2015 ) Obesity is a major growing health concern around the world. In most markets, a person is considered obese if their Body Mass Index (BMI) exceeds 30 kilograms per square meter (kg/m2), calculated by dividing body mass in kilograms by height in meters squared. With the global prevalence continuing to rise, the disease has placed significant burden on healthcare expenditure, as it is also a major risk factor for cardiovascular diseases, diabetes and cancer.
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Anti-obesity pharmacotherapy can be used as an adjunct lifestyle modification to improve weight loss in order to significantly reduce obesity-associated health risks in obese patients. However, the use of currently available anti-obesity drugs is largely limited by poor long-term safety and a modest weight loss effect. Despite substantial clinical and regulatory challenges, the early-stage obesity pipeline remains robust, containing a high level of first-in-class innovation that has the potential to be translated into effective and safe weight loss treatments.
List of Figures and Tables:
Table 1: The International Classification of Underweight, Overweight and Obesity in Adults 13
Table 2: Treatment Options Dependent on Body Mass Index 15
Figure 1: Innovation Trends in Product Approvals, 1987–2013 5
Figure 2: Sales Performance of First-in-Class and Non-First-in-Class Products Post Marketing Approval, 2006–2013 7
Figure 3: Molecular Targets of Marketed Products, 2015 19
Figure 4: Developmental Pipeline Overview 23
Figure 5: Players in the Obesity Pipeline 24
Figure 6: Developmental Pipeline Overview 25
Figure 7: Molecular Target Category Comparison, Pipeline and Marketed Products 26
Figure 8: Molecular Target Category Comparison, Pipeline First-in-Class and Established Molecular Targets 28
Figure 9: Obesity, Global, First-in-Class Pipeline Products 29
Figure 10: Signaling Networks of Functional Families in Obesity 33
Figure 11: Location of Key First-in-Class Targets within the Signaling Matrix 34
Figure 12: First-in-Class Molecular Target Analysis Matrix 36...
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Scope:
Historically, the obesity market has suffered from long-term safety concerns and modest efficacy with current treatments, both of which contribute to the low prescription rate and limited widespread use.
What are the main safety concerns that lead to significant challenges in gaining drug approval in obesity?
Why is sustainable weight loss difficult to achieve, and what is the implication for future drug development?
Analysis reveals a high level of innovation and diversity in the pipeline, with 75 first-in-class programs identified to act on 60 unique molecular targets.
What is the dominant target family across these first-in-class pipeline products?
How well do they align with the underlying signaling pathways governing the central and peripheral regulation of food intake, and energy expenditure?
Some first-in-class targets are deemed more likely to be developed into marketable treatments than others, having demonstrated substantial body weight reduction in
Preclinical studies and addressing multiple mechanisms underpinning the development of obesity…
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