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(Medical-NewsWire.com, July 07, 2013 ) San Francisco, CA -- A two-year study resulted in the publication, this month, of its findings in the Proceedings of the National Academy of Science. The publication described the results from a two-year randomized, controlled clinical trial involving a high-dose vitamin B treatment for Alzheimer’s disease.
The study was conducted by researchers from the FMRIB Centre at the University of Oxford, in the United Kingdom. Research showed positive but inconclusive results in the prevention of dementia and cognitive decline brought about by grey matter atrophy in Alzheimer’s patients.
This was not the first time vitamin B supplements have been used in clinical trials for the treatment of Alzheimer’s disease and most other studies did not produce positive results. One of the authors of the study, Dr. Gwenaelle Douaud commented, "We simply used vitamin B
supplements that already exists and are available (vitamin B12, which was the most effective, folate, B6) and it was administered daily as a pill."
Douaud speculates that the promising data obtained from this study was because most of the subjects were still in the early stages of dementia. The homocysteine levels of the patients were only moderately elevated. The reason the subjects responded so well to treatment was that the disease was still in its early stages. The patients were thoroughly scanned and tested both before and after treatment. This ensured the researchers had “a robust and unbiased way of assessing changes of a longer-term nature, including the impact of the treatment."
Douaud was cautiously optimistic when asked if vitamin B could be used as a form of treatment. "This is too early to say. What we have shown is that, in these elderly people at risk for dementia and with high levels of homocysteine, you can slow the grey matter loss in the areas of the brain that matter, and therefore slow their cognitive decline. However, we would need a larger and longer trial to determine the optimal threshold of homocysteine that would warrant vitamin B supplementation and, crucially, if this could therefore slow the progression of Alzheimer's," she concluded.
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