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(Medical-NewsWire.com, September 15, 2021 ) Market Overview
Proteinase K is a typical member of the subtilisin family of proteinases. Proteinase K is able to digest hair (keratin), hence, the name "Proteinase K". The predominant site of cleavage is the peptide bond adjacent to the carboxyl group of aliphatic and aromatic amino acids with blocked alpha amino groups. It is commonly used for its broad specificity. This enzyme belongs to Peptidase family S8 (subtilisin). The molecular weight of Proteinase K is 28,900 daltons (28.9 kDa). Proteinase K is used for the destruction of proteins in cell lysates (tissue, cell culture cells) and for the release of nucleic acids since it very effectively inactivates DNases and RNases.
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The Proteinase K market is to witness positive growth owing to higher research, development activities, and investments by institutions, pharmaceutical, and biopharmaceutical companies in innovation. The growing use of Proteinase K in drug discovery and disease diagnosis will affect the market positively. However, purity issues like the presence of other proteins and nucleases and the low thermal stability of Proteinase K can hamper the market.
Increasing research and development activities will drive the market growth
The increasing adoption of proteinase K in the R&D of rare diseases is one of the major factors that is going to offer lucrative growth opportunities. For instance, in April 2019, researchers from Scripps Research reported that labeling light chains with fluorophores and coupling shape changes to cleavage by proteinase K in order to identify a group of small molecules that prevent structural changes to proteins that that cause AL amyloidosis, a rare and progressive disease.
In drug discovery and disease diagnosis
Fine-needle aspiration biopsy or FNAB is an important tool used in medical research. It is widely adopted, thanks to its simplicity, cost-effectiveness, and safety for diagnosing thyroid disease. Conventionally, the disease is diagnosed with the cytopathological examination. However, newer methods like liquid-based cytology are proving to be more advantageous with more accuracy in results. Proteinase K cells used for RNA extraction in this process are emerging as a key problem-solver for cancer-derived K1 cells and FNAB specimens. The proteinase K is likely to solve challenges relating to RNA isolation and cell recovery in liquid-based cytology. This is a major development in the Proteinase K market and can open tremendous new opportunities for existing players.
The proteinase K products are used in tissue engineering and many other types of research.
Side Effects Associated with the impurity and low thermal stability
The new sophisticated DNA purification technologies can hamper the market. The presence of impurities in proteinase K can affect its use. Low thermal stability of proteinase K limits the hydrolysis and aminolysis reactions in industrial processes, which is expected to hamper the growth of the market over the forecast period. The thermal stability of proteinase K limits its practical potential as an efficient catalyst.
• Lyophilized Powder
• Purification of RNA&DNA
• In situ Hybridization
• Bio-Pharmaceutical Companies
• Pharmaceutical Companies
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North America will see growth in the market over the forecast period
An increasing number of diseases and polymerase chain reaction applications found will boost the market in this region. Along with increased government funding and more R&D in the life science sector this region will see a rise in the market in the forecast period.
Moreover, with the emergence of COVID-19, the use of proteinase K increased, and new products were developed.
According to the Pharmaceutical Research and Manufacturers Association (PhRMA), 2018, US firms conduct over half the world's R&D in pharmaceuticals. Approximately 79.6 billion was invested in biopharmaceutical research and development in the United States in 2018.
The proteinase K market is moderately competitive. Major players operating in the global proteinase K market include Thermo Fisher Scientific Inc., Merck KGaA, Qiagen N.V., Sisco Research Laboratories Pvt. Ltd.., New England Biolabs, Worthington Biochemical Corporation, Norgen Biotek Corp., BIORON GmbH, Sisco Research Laboratories Pvt. Ltd., Bioline (Meridian Biosciences Inc.), and Promega Corporation.
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